COVID Reactivates And Triggers Potential Causes Of Long COVID
Reference Article Linked Here.
We’d love to be able to predict just who will get long COVID. We can’t yet say for sure who would get Long COVID but we are developing the capacity to understand it a bit better. This study is an elegant study of genomics and immune activation. If you are into detailed studies of genomes then you’ll love this study.
For our summary, there are a few key points:
Long COVID sufferers often have depressed cortisol and cortisone. This may be because of the use of steroids in COVID especially if they have been used over weeks and months. Those who have low levels of cortisone and cortisol have associated Long COVID
COVID seems to reactivate Epstein-Barre Virus which could trigger Long COVID n the brain. It also triggers the production of autoantibodies associated with autoimmune disease like Systemic Lupus Erythematosus and tht work against Interferon molecules. The end result is increasing autoimmune burden and inflammation with increasing inflammatory cytokines.
Pre-existing conditions including Diabetes make Long COVID more likely, Diabetes is an inflammatory condition.
Reactivating certain types of immune cells in the gut also seem to contribute to Long COVID in the gut.
Bottom line: be sure to check EBV DNA titers, antinuclear antibodies levels, and cortisol levels. Each could provide a clue at future treatment plans. Additional specialized testing may be necessary.
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